LISTERINE® Antiseptic Mouthwash: Was shown in a clinical study to reduce 52% more plaque and 21% more gingivitis than brushing and flossing alone. Is the only nationally branded antimicrobial mouthwash to receive the ADA Seal of Acceptance for fighting plaque and gingivitis. Has over 100 years of safe use and 50 years of research, making it the most widely used and extensively researched mouthwash in the U.S. "The ADA Council on Scientific Affairs' Acceptance of Listerine Antiseptic is based on its finding that the product is effective in helping to prevent and reduce gingivitis and plaque above the gumline, when used as directed."