Growing evidence suggests that inflammation which begins in the mouth as gingivitis and develops into periodontitis** may be associated with systemic inflammation. Systemic inflammation may, in turn, contribute to other health problems. Colgate Total 12 is the only toothpaste with a unique formula that attaches to teeth to provide a 12-hour protective shield that helps reduce gingivitis. Brushing with Colgate Total 12 is a simple step that you can take each day to help stay healthy.